ea0022oc2.2 | Thyroid | ECE2010
Klutz Kathrin
, Schaffert David
, Rodl Wolfgang
, Willhauck Michael J
, Cengizeroglu Arzu
, Wunderlich Nathalie
, Gildehaus Franz Josef
, Wagner Ernst
, Goke Burkhard
, Ogris Manfred
, Spitzweg Christine
We have recently demonstrated induction of tumor-selective accumulation and therapeutic efficacy of radioiodine in neuroblastoma tumors after systemic non-viral polyplex-mediated sodium-iodide-symporter (NIS) gene delivery.In the current study, we evaluated the efficacy of novel synthetic nanoparticle vectors based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (PEG), and coupled with the synthetic peptide GE11 as an epidermal growth ...